| Date | Player | Pos. | Transaction |
| 5/16 | Mitch Stetter | P | Sent to Minors |
| 5/16 | Zach Jackson | P | Called Up from Minors |
| 5/15 | Ryan Braun | LF | Signed, ( 2008-2015)(seven-year extension) |
| 5/15 | David Riske | P | Placed on 15-Day DL, (Hyperextended right elbow) |
| 5/9 | Derrick Turnbow | P | Outrighted to Minors |
| 5/3 | Yovani Gallardo | P | Placed on 15-Day DL, (Torn ACL, right knee) |
| 5/3 | Dave Bush | P | Called Up from Minors |
| 5/2 | Derrick Turnbow | P | Designated for Assignment |
| 5/2 | Joe Dillon | LF | Called Up from Minors |
| 4/29 | Mike Cameron | CF | Reinstated from Illegal Substance Suspension |
| 4/27 | Dave Bush | P | Sent to Minors |
| 4/23 | Tony Gwynn | CF | Removed From 15-Day DL, (Strained left hamstring) |
| 4/22 | Tony Gwynn | CF | Recalled From Minors, Rehab Assignment |
| 4/20 | Joe Dillon | 2B | Sent to Minors |
| 4/20 | Yovani Gallardo | P | Removed From 15-Day DL, (Torn lateral meniscus, left knee) |
| 4/20 | Yovani Gallardo | P | Recalled From Minors, Rehab Assignment |
| 4/17 | Mitch Stetter | P | Called Up from Minors |
| 4/17 | Hernan Iribarren | 2B | Sent to Minors |
| 4/17 | Tony Gwynn | CF | Sent to Minors, For Rehabilitation |
| 4/15 | Jeff Weaver | P | Signed to a Minor League Contract |
| 4/13 | Yovani Gallardo | P | Sent to Minors, For Rehabilitation |
| 4/9 | Yovani Gallardo | P | Recalled From Minors, Rehab Assignment |
| 4/9 | Tony Gwynn | CF | Placed on 15-Day DL, (Strained left hamstring) |
| 4/4 | Yovani Gallardo | P | Sent to Minors, For Rehabilitation |
| 3/30 | Mike Cameron | CF | Starting to Serve Illegal Substance Suspension |
| 3/27 | Chris Capuano | P | Placed on 15-Day DL, (Sprained ligament, left elbow) |
| 3/26 | Eric Munson | C | Outrighted to Minors |
| 3/25 | Claudio Vargas | P | Released |
| 3/21 | Mitch Stetter | P | Sent to Minors |
| 3/21 | Yovani Gallardo | P | Placed on 15-Day DL, (Torn lateral meniscus, left knee) |
| 3/21 | Vinny Rottino | 1B | Sent to Minors |
| 3/20 | Randy Choate | P | Placed on 15-Day DL, (Fractured left hand) |
| 3/14 | Zach Jackson | P | Sent to Minors |
| 3/11 | Lou Palmisano | | Sent to Minors |
| 3/3 | Scott Cassidy | P | Retired |
| 2/20 | Russell Branyan | 3B | Signed to a Minor League Contract |
| 2/16 | J.J. Hardy | SS | Signed, ( 2008)(avoids arbitration) |
| 2/5 | Dave Bush | P | Signed, ( 2008)(avoids arbitration) |
| 1/23 | Abraham Nunez | 3B | Signed to a Minor League Contract |
| 1/18 | Chris Capuano | P | Signed, ( 2008)(avoids arbitration) |
| 1/16 | Claudio Vargas | P | Signed, ( 2008)(avoids arbitration) |
| 1/15 | Drew Anderson | LF | Designated for Assignment |
| 1/14 | Mike Cameron | CF | Signed as Free Agent, ( 2008; Opt 2009) |
| 1/11 | Mike Cameron | CF | Signed as Free Agent, ( 2008) |
| 1/9 | Brian Shouse | P | Signed, ( 2008)(avoids arbitration) |
| 12/20 | Gabe Kapler | RF | Signed as Free Agent, ( 2008) |
| 12/12 | Kevin Mench | LF | Not Offered Contract and Became Free Agent, (non-tendered) |
| 12/11 | Greg Aquino | P | Signed, ( 2008)(avoids arbitration) |
| 12/10 | Kevin Mench | LF | Designated for Assignment |
| 12/10 | Eric Gagne | P | Signed as Free Agent, ( 2008) |
| 12/7 | Salomon Torres | P | Traded From, Pittsburgh (for RHPs Marino Salas and Kevin Roberts) |
| 12/6 | Brett Campbell | P | Drafted Via Rule 5 from Minors, (Triple-A phase) |
| 12/5 | David Riske | P | Signed as Free Agent, ( 2008-2010)(three-year contract) |
| 12/5 | Laynce Nix | CF | Designated for Assignment |
| 12/4 | Chris Narveson | P | Signed to a Minor League Contract |
| 12/4 | Scott Cassidy | P | Signed to a Minor League Contract |
| 11/28 | Jason Kendall | C | Signed as Free Agent, ( 2008; Opt 2009) |
| 11/21 | Jason Kendall | C | Signed as Free Agent, ( 2008; Opt 2009) |
| 11/20 | Guillermo Mota | P | Traded From, NY Mets (for C Johnny Estrada) |
| More Transactions |
| Posted Sat May 17 02:27:52 EDT 2008 |
