| Date | Player | Pos. | Transaction |
| 5/16 | Richie Sexson | 1B | Reinstated From League Suspension |
| 5/10 | Richie Sexson | 1B | Starting to Serve Suspension |
| 5/9 | Richie Sexson | 1B | Suspension Announced By League, (five games) |
| 5/8 | Brad Wilkerson | RF | Cleared Waivers and Became a Free Agent |
| 4/30 | Wladimir Balentien | CF | Called Up from Minors |
| 4/30 | Jeff Clement | C | Called Up from Minors |
| 4/30 | Brad Wilkerson | RF | Designated for Assignment |
| 4/30 | Greg Norton | 1B | Designated for Assignment |
| 4/26 | Erik Bedard | P | Removed From 15-Day DL, (Left hip inflammation) |
| 4/26 | Roy Corcoran | P | Sent to Minors |
| 4/25 | Kenji Johjima | C | Signed, ( 2008-2011)(three-year extension) |
| 4/22 | R.A. Dickey | P | Sent to Minors |
| 4/22 | J.J. Putz | P | Removed From 15-Day DL, (Right torso inflammation) |
| 4/19 | Anderson Garcia | P | Sent to Minors, For Rehabilitation |
| 4/16 | Charlton Jimerson | RF | Released |
| 4/16 | Charlton Jimerson | RF | Signed to a Minor League Contract |
| 4/16 | Brandon Morrow | P | Called Up from Minors |
| 4/15 | Erik Bedard | P | Placed on 15-Day DL, (Left hip inflammation) |
| 4/14 | Eric O'Flaherty | P | Sent to Minors |
| 4/14 | Arthur Rhodes | P | Purchased From Minors |
| 4/14 | R.A. Dickey | P | Called Up from Minors |
| 4/14 | Mike Morse | 1B | Placed on 15-Day DL, (Dislocated left shoulder) |
| 4/11 | Charlton Jimerson | RF | Designated for Assignment |
| 4/11 | Greg Norton | RF | Purchased From Minors |
| 4/2 | Roy Corcoran | P | Purchased From Minors |
| 4/2 | J.J. Putz | P | Placed on 15-Day DL, (Right torso inflammation) |
| 3/30 | Anderson Garcia | P | Placed on 15-Day DL, (Right shoulder tendinitis) |
| 3/26 | Ryan Feierabend | P | Sent to Minors |
| 3/25 | Kevin Witt | 1B | Signed to a Minor League Contract |
| 3/24 | Rob Johnson | C | Sent to Minors |
| 3/24 | Wladimir Balentien | CF | Sent to Minors |
| 3/19 | Cesar Jimenez | P | Sent to Minors |
| 3/19 | Jon Huber | P | Sent to Minors |
| 3/19 | Jeff Clement | C | Sent to Minors |
| 3/19 | Sean White | P | Sent to Minors |
| 3/12 | Horacio Ramirez | P | Released |
| 3/8 | Bubba Crosby | CF | Released |
| 3/8 | Denny Stark | | Signed to a Minor League Contract |
| 2/23 | Mike Kinkade | 1B | Signed to a Minor League Contract |
| 2/19 | Bubba Crosby | CF | Signed to a Minor League Contract |
| 2/16 | Anderson Garcia | P | Acquired Off Waivers From, Philadelphia |
| 2/15 | Erik Bedard | P | Signed, ( 2008)(avoids arbitration) |
| 2/13 | Greg Norton | RF | Signed to a Minor League Contract |
| 2/8 | Erik Bedard | P | Traded From, Baltimore (for OF Adam Jones in six-player deal) |
| 1/31 | Brad Wilkerson | 1B | Signed as Free Agent, ( 2008) |
| 1/18 | Horacio Ramirez | P | Signed, ( 2008)(avoids arbitration) |
| 1/16 | Bronson Sardinha | LF | Signed to a Minor League Contract |
| 1/16 | Roy Corcoran | P | Signed to a Minor League Contract |
| 1/16 | Phil Barzilla | P | Signed to a Minor League Contract |
| 1/15 | George Sherrill | P | Signed, ( 2008)(avoids arbitration) |
| 1/15 | Arthur Rhodes | P | Signed to a Minor League Contract |
| 1/10 | Chris Reitsma | P | Signed to a Minor League Contract |
| 1/8 | Miguel Cairo | 1B | Signed as Free Agent |
| 12/20 | Carlos Silva | P | Signed as Free Agent, ( 2008-2011)(four-year contract) |
| 12/12 | John Parrish | P | Not Offered Contract and Became Free Agent, (non-tendered) |
| 12/6 | R.A. Dickey | P | Drafted Via Rule 5 from Minors |
| More Transactions |
| Posted Sat May 17 13:02:52 EDT 2008 |
