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American League · National League
| Free Agents | Pos. | Status | | Kevin Cash | C | Re-signed (minor league deal) | | Royce Clayton | SS | | | Bobby Kielty | OF | Re-signed (minor league deal) | | Mike Lowell | 3B | Re-signed ($37.5M, 3 years) | | Doug Mirabelli | C | Re-signed ($550K, 1 year) | | Curt Schilling | RHP | Re-signed ($8M, 1 year) | | Julian Tavarez | RHP | Re-signed ($3.85M option) | | Mike Timlin | RHP | Re-signed ($3M, 1 year) | | Tim Wakefield | RHP | Re-signed ($4M option) |
| Arbitration Eligible | Pos. | Status | | Javier Lopez | LHP | Re-signed ($840K, 1 year) | | Kyle Snyder | RHP | Re-signed ($835K, 1 year) | | Kevin Youkilis | 1B | Re-signed ($3M, 1 year) |
| Acquired | Pos. | Status | | David Aardsman | RHP | Traded from CHW | | Scott Atchison | RHP | Signed (minor league deal) | | Sean Casey | 1B | Signed ($800K, 1 year) | | Bartolo Colon | RHP | Signed (minor league deal) | | Lee Gronkiewicz | RHP | Signed (minor league deal) | | Dan Kolb | RHP | Signed (minor league deal) | | Dan Miceli | RHP | Signed (minor league deal) |
| Departed | Pos. | Status | | Matt Clement | RHP | Signed with STL ($1.5M, 1 year) | | Brendan Donnelly | RHP | Signed with CLE (minor league deal) | | Eric Gagne | RHP | Signed with MIL ($10M, 1 year) | | Eric Hinske | 1B | Signed with TB (minor league deal) | | Jay Marshall | LHP | Claimed off waivers by OAK |
| Free Agents | Pos. | Status | | Reggie Sanders | OF | | | John Thomson | RHP | |
| Arbitration Eligible | Pos. | Status | | John Buck | C | Re-signed ($2.2M, 1 year) | | Ramon Colon | RHP | Re-signed (minor league deal) | | Jorge De La Rosa | LHP | Re-signed ($1.025M, 1 year) | | Brandon Duckworth | RHP | Re-signed ($600K, 1 year) | | Ben Hendrickson | RHP | Re-signed (minor league deal) | | Luke Hudson | RHP | Re-signed (1 year) | | Esteban German | INF | Re-signed (1 year) | | Ross Gload | 1B/OF | Re-signed ($3.2M, 2 years) | | Jimmy Gobble | LHP | Re-signed ($1.31M, 1 year) | | Zack Greinke | RHP | Re-signed ($1.4M, 1 year) | | Jason Smith | INF | Re-signed (1 year) | | Mike Stodolka | 1B | Re-signed (minor league deal) | | Mark Teahen | OF | Re-signed ($2.337M, 1 year) | | Matt Wright | RHP | Re-signed (minor league deal) |
| Acquired | Pos. | Status | | Alberto Callaspo | INF | Traded from ARI | | Jose Guillen | OF | Signed ($36M, 3 years) | | Tim Hamulack | LHP | Signed (minor league deal) | | Ray Liotta | LHP | Selected from CHW in Rule 5 draft | | Ron Mahay | LHP | Signed ($8M, 2 years) | | Mike Maroth | LHP | Signed (minor league deal) | | Hideo Nomo | RHP | Signed (minor league deal) | | Miguel Olivo | C | Signed (1 year) | | Matt Peterson | RHP | Signed (minor league deal) | | Brett Tomko | RHP | Signed ($3M, 1 year) | | Chin-hui Tsao | RHP | Signed (minor league deal) | | Yasuhiko Yabuta | RHP | Signed (from Japan) |
| Departed | Pos. | Status | | Wes Bankston | 1B | Claimed off waivers by OAK | | Emil Brown | OF | Signed with OAK (1 year) | | Billy Buckner | RHP | Traded to ARI | | Jason LaRue | C | Signed with STL (1 year) | | Odalis Perez | LHP | Signed with WAS (minor league deal) | | Paul Phillips | C | Signed with CHW (minor league deal) | | David Riske | RHP | Signed with MIL (3 years) | | Mike Sweeney | DH | Signed with OAK (minor league deal) |
| Free Agents | Pos. | Status | | Rondell White | OF | |
| Arbitration Eligible | Pos. | Status | | Michael Cuddyer | RF | Re-signed ($24M, 3 years) | | Matt Guerrier | RHP | Re-signed ($950K, 1 year) | | Jason Kubel | LF | Re-signed ($1.3M, 1 year) | | Justin Morneau | 1B | Re-signed ($7.4M, 1 year) | | Juan Rincon | RHP | Re-signed (1 year) |
| Acquired | Pos. | Status | | Brian Bass | RHP | Signed (1 year) | | Zach Day | RHP | Signed (minor league deal) | | Adam Everett | SS | Signed ($2.8M, 1 year) | | Carlos Gomez | OF | Traded from NYM | | Deolis Guerra | RHP | Traded from NYM | | Brendan Harris | SS | Traded from TB | | Livan Hernandez | RHP | Signed ($5M, 1 year) | | Philip Humber | RHP | Traded from NYM | | Randy Keisler | LHP | Signed (minor league deal) | | Mike Lamb | INF | Signed ($6.6M, 2 years) | | Craig Monroe | OF | Signed ($3.82M, 1 year) | | Kevin Mulvey | RHP | Traded from NYM | | Jason Pridie | OF | Traded from TB | | Delmon Young | RF | Traded from TB |
| Departed | Pos. | Status | | Jason Barlett | SS | Traded to TB | | Matt Garza | RHP | Traded to TB | | Chris Heintz | C | Signed with BAL (minor league deal) | | Torii Hunter | CF | Signed with ANA ($90M, 5 years) | | Eduardo Morlan | RHP | Traded to TB | | Luis Rodriguez | INF | Claimed off waivers by SD | | Johan Santana | LHP | Traded to NYM | | Carlos Silva | RHP | Signed with SEA ($48M, 4 years) | | Jason Tyner | OF | Signed with CLE (minor league deal) |
| Free Agents | Pos. | Status | | Bobby Abreu | RF | Re-signed ($16M option) | | Roger Clemens | RHP | | | Jose Molina | C | Re-signed ($4M, 2 years) | | Jorge Posada | C | Re-signed ($52.4M, 4 years) | | Mariano Rivera | RHP | Re-signed ($45M, 3 years) | | Alex Rodriguez | 3B | Re-signed ($275M, 10 years) |
| Arbitration-Eligible | Pos. | Status | | Wilson Betemit | 3B | Re-signed ($1.165M, 1 year) | | Brian Bruney | RHP | Re-signed ($725K, 1 year) | | Robinson Cano | 2B | Re-signed ($28M, 4 years) | | Andy Pettitte | LHP | Signed ($16M, 1 year) | | Chien-Ming Wang | RHP | Re-signed ($4M, 1 year) |
| Acquired | Pos. | Status | | Jonathan Albaladejo | RHP | Traded from WAS | | Morgan Ensberg | 3B | Signed (purchased from minors) | | LaTroy Hawkins | LHP | Signed ($3.75M, 1 year) | | Jason Lane | OF | Signed (minor league deal) | | Chad Moeller | C | Signed (minor league deal) | | Heath Phillips | LHP | Signed (minor league deal) | | Chris Woodward | INF | Signed (minor league deal) |
| Departed | Pos. | Status | | Jim Brower | RHP | Signed with CIN (minor league deal) | | Tyler Clippard | RHP | Traded to WAS | | Matt DeSalvo | RHP | Signed with ATL (minor league deal) | | Michael Gardner | RHP | Selected by SD in Rule 5 draft | | Doug Mientkiewicz | 1B | Signed with PIT ($750K, 1 year) | | Andy Phillips | 1B | Signed with CIN (minor league deal) | | Bronson Sardinha | RF | Signed with SEA (minor league deal) | | Ron Villone | LHP | Signed with STL (minor league deal) | | Luis Vizcaino | RHP | Signed with COL ($7.5M, 2 years) |
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