| Week 1 - Thursday, Sep. 4, 2008 |
| Washington Redskins at NY Giants |
 | Giants: |
 | Redskins: |
| Week 1 - Sunday, Sep. 7, 2008 |
| Jacksonville Jaguars at Tennessee Titans |
 | Titans: |
 | Jaguars: |
| Houston Texans at Pittsburgh Steelers |
 | Steelers: |
 | Texans: |
| St. Louis Rams at Philadelphia Eagles |
 | Eagles: |
 | Rams: |
| Tampa Bay Buccaneers at New Orleans Saints |
 | Saints: |
 | Buccaneers: |
| Kansas City Chiefs at New England Patriots |
 | Patriots: |
 | Chiefs: |
| NY Jets at Miami Dolphins |
 | Dolphins: |
 | Jets: |
| Seattle Seahawks at Buffalo Bills |
 | Bills: |
 | Seahawks: |
| Cincinnati Bengals at Baltimore Ravens |
 | Ravens: |
 | Bengals: |
| Detroit Lions at Atlanta Falcons |
 | Falcons: |
 | Lions: |
| Arizona Cardinals at San Francisco 49ers |
 | 49ers: |
 | Cardinals: |
| Carolina Panthers at San Diego Chargers |
 | Chargers: |
 | Panthers: |
| Dallas Cowboys at Cleveland Browns |
 | Browns: |
 | Cowboys: |
| Chicago Bears at Indianapolis Colts |
 | Colts: |
 | Bears: |
| Week 1 - Monday, Sep. 8, 2008 |
| Minnesota Vikings at Green Bay Packers |
 | Packers: |
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| Denver Broncos at Oakland Raiders |
 | Raiders: |
 | Broncos: |
