| Neil O'Donnell QB, Tennessee Titans |
| Matt O'Dwyer G, Cincinnati Bengals |
| Shaun O'Hara C, Cleveland Browns |
| Dan O'Leary TE, Buffalo Bills |
| Andre O'Neal LB, Minnesota Vikings |
| Deltha O'Neal CB, Denver Broncos |
| Dennis O'Sullivan DT, New York Jets |
| Roman Oben T, Cleveland Browns |
| Ron Ockimey DB, San Francisco 49ers |
| Kendrick Office DE, Buffalo Bills |
| Andre Offing LB, Detroit Lions |
| Eric Ogbogu DE, New York Jets |
| Jeff Ogden WR, Miami Dolphins |
| Jonathan Ogden T, Baltimore Ravens |
| Cedric Oglesby K, Arizona Cardinals |
| Adewale Ogunleye DE, Miami Dolphins |
| Ifeanyi Ohalete DB, Washington Redskins |
| Onomo Ojo WR, New Orleans Saints |
| Chike Okeafor DE, San Francisco 49ers |
| Chukky Okobi C, Pittsburgh Steelers |
| Chris Oldham DB, New Orleans Saints |
| Kautai Olevao LB, Tennessee Titans |
| Brock Olivo RB, Detroit Lions |
| Hans Olsen DT, Indianapolis Colts |
| Benji Olson G, Tennessee Titans |
| Erik Olson DB, Jacksonville Jaguars |
| Scot Osborne TE, Buffalo Bills |
| Jerry Ostroski G, Buffalo Bills |
| Wes Ours RB, Indianapolis Colts |
| Rich Owens DE, Kansas City Chiefs |
| Terrell Owens WR, San Francisco 49ers |